State of the art
The use of individual Volatile Organic Compounds (VOCs) as biomarkers of exposure or disease is hampered by the fact that using a single compound is generally insufficient to monitor complex and heterogeneous processes including environmental exposures or chronic diseases.
Therefore, exploring the presence and relations of exhaled VOCs, called the volatome, is expected to generate more adequate information regarding the processes involved. Certainly, analysing the volatome implies a more specific discrimination between various conditions as it reflects changes in both exogenous and endogenous compounds.
One technique that allows for the detection of the volatome is gas chromatography-deep ultraviolet spectroscopy (GC-DUV). It has been used both for the assessment of environmental factors as well as for individual VOCs.
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